Bioinformatiker (m/w/d) (Bioinformatiker/in)

Düsseldorf University Hospital (UKD) is the largest hospital in the state capital and one of the most important medical centers in North Rhine-Westphalia. The 9,300 employees at UKD and its subsidiaries are committed to treating over 45,000 inpatients and 270,000 outpatients every year. The UKD stands for international excellence in patient care, research and teaching, as well as for innovative and safe diagnostics, therapy and prevention. Patients benefit from the intensive interdisciplinary cooperation between the 60 clinics and institutes. The particular strength of the University Hospital is the close integration of clinical and research work for the safe application of new methods. Tomorrow's medicine is being created at the UKD. Every day.

The Department of Rheumatology and Hiller Research Center from the Heinrich-Heine-University and University Hospital Düsseldorf invites applications for a:

Bioinformatician / Statistician (m/f/d) - OMICs in rheumatic diseases, statistical evaluation of clinical databases, planning for clinical trials

We are seeking a highly motivated bioinformatician / statistician with experience in all of the following areas:

the evaluation of different OMICs datasets (including bulk and sc RNASeq, imaging mass cytometry, cyclic in situ hybridization, spatial transcriptomics), the integration of different OMICs
statistical evaluation of biomedical databases, if possible, with pre-experience in rheumatologic diseases
statistical planning (e.g. power calculations) for clinical trials
Programming in different computer languages, i.p. “R”
Presentation of the results: Publications, oral presentations
The major goal of our group is to characterize pathogenic mechanisms of chronic inflammatory diseases associated with tissue remodeling, and to identify novel treatment strategies for these diseases.

We are an international research group with members from different backgrounds, including biologists and clinicians, and with close collaborations with researchers from other fields such as bioinformatics, which ensures an interdisciplinary environment. We have unrestricted access to state-of-the-art technologies including next generation sequencing, mass cytometry, advanced imaging techniques. The position is evaluated according to E 13 Tv-L. In accordance to the employment prerequisites of § 44 Abs. 4 Hochschulgesetz NRW, the applicant should have a PhD degree at the time of application, or be in the concrete finalizing stages, with the perspective of obtaining the PhD degree within six months after application.

The employment contract is concluded with Heinrich Heine University.

Heinrich Heine University Düsseldorf aims to increase the proportion of women. Applications from women with equal suitability, qualifications and professional performance will therefore be given preferential consideration, unless reasons relating to the person of a competitor outweigh this. The application of suitable severely disabled persons and persons with equivalent disabilities according SGB IX is welcome.

Düsseldorf University Hospital (UKD) is the largest hospital in the state capital and one of the most important medical centers in North Rhine-Westphalia. The 9,300 employees at UKD and its subsidiaries are committed to treating over 45,000 inpatients and 270,000 outpatients every year. The UKD stands for international excellence in patient care, research and teaching, as well as for innovative and safe diagnostics, therapy and prevention. Patients benefit from the intensive interdisciplinary cooperation between the 60 clinics and institutes. The particular strength of the University Hospital is the close integration of clinical and research work for the safe application of new methods. Tomorrow's medicine is being created at the UKD. Every day.

A central aspect of the CARDDIAB research network is the investigation of metabolic dysfunctions and their relationship with cardiovascular diseases. To investigate cardiometabolic interactions between the organs, high-throughput data are collected from dedicated cohorts. The aim is to gain insights into previously poorly understood cardiometabolic aspects, particularly in the development of diabetes.
The research group “Algorithms of Cardiometabolic Fluxomics” in the Department for Endocrinology and Diabetology at the Medical Faculty develops computational methods for the analysis of multimodal data (genome, transcriptome, epigenome, proteome, metabolome) and is looking for a highly motivated and talented
Postdoctoral Researcher (m/f/x) in Bioinformatics

full-time (100% TV-L E13)
Employment will start as soon as possible and last for 21 months with possible extension.
Carry out cutting edge research in bioinformatics and medical data science
Develop bioinformatics tools for the analysis of Capture Hi-C sequencing data in a longitudinal study
Analyze single-cell sequencing data for the reconstruction of cell lineages
Contribute to a collaborative and interdisciplinary research initiative at the intersection of bioinformatics and medical research.

Doctoral degree/Ph.D. in bioinformatics/computational biology, or related areas
Experience with RNA-seq / HI-C / ChIP-Seq data analysis
Programming skills with Python or R
Good track record of scientific publications
Good communication skills (English)
Interest in interdisciplinary collaboration
Independent, responsible and committed work attitude

Desirable qualifications:

Successful interdisciplinary research collaborations
Organizational and coordination skills
First experiences in raising third-party funds
Experience in supervising student projects and Bachelor/Master theses
International research experience / working experience abroad

The position is based on the German Academic Fixed-Term Contract Act (WissZeitVG according to § 2 p. 2), initially for a fixed term of 21 months until the end of the project with the possibility of extension
Remuneration according to TV-L E13
Space for personal responsibility, creativity and personal development
Flexible and family-friendly working time models
Childcare options in a UKD day-care center and offers for those returning from parental leave
38,5 (100%) working hours per week
Inexpensive catering options on the UKD site
Company pension scheme (VBL supplementary pension in the public sector)