PhD Student Biology - Molecular Biology (m/f/d)

JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG, GERMANY
Institute for Molecular Infection Biology (IMIB)

PhD Student position (f/m/d)
“Regulation of early spliceosome assembly and splice site recognition”




Applications are invited for a PhD student position in the Beusch group at the Institute of Molecular Infection Biology at the University of Würzburg. Successful candidates will work in an interdisciplinary project aiming at understanding the initial steps in RNA splicing regulation and spliceosome assembly. Splicing is an essential step in post-transcriptional processing. Mutations that disrupt splicing have often deleterious consequences, causing a wide range of diseases from neuromuscular disorders to cancer. Our research group’s goal is to gain a detailed mechanistic understanding of splicing and its regulation within the cell to not only understand fundamental eukaryotic biology but also human disease. In particular, we focus on understanding how splice site choice occurs and how this interplays with the assembly of the spliceosome. The spliceosome is a highly complex molecular machine, which will assemble de novo from over 150 proteins and 5 small nuclear RNAs for each reaction that it catalyses. What fascinates us is not only how this assembly is regulated but how the spliceosome can handle its very diverse substrate pool. To do so, we use forward genetics (CRISPR-Cas9 base editing screens, CRISPR-Cas9 genome engineering) in combination with a wide range of technologies including RNA-seq approaches as well as molecular biology methods (e.g. proximity labelling, IP-MS) and biochemistry
A Master’s degree in life science and a strong background in either RNA biology or biochemistry.
Experience in molecular biology, tissue culture and cell line engineering, RNA-seq data analysis, and bioinformatics is welcome.
Good written and spoken English-language communication skills, and interest in working as part of an international team of researchers.
An interest in RNA biology, or desire to learn.
We welcome applications from suitably qualified people from all sections of the community regardless of race, gender or disability. The University aims to increase the proportion of female employees, therefore applications from qualified women are particularly welcome. Preference will be given to people with disabilities in the case of otherwise equal aptitude. The position is initially limited to 1 year with the possibility of extension upon good progress. Salary will be based on the pay scale for the public sector in Germany (TV-L).
For informal inquiries, please feel free to contact Dr. Irene Beusch ([email protected]).

JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG, GERMANY
Institute for Molecular Infection Biology (IMIB)

PhD Student position (f/m/d)
“Regulation of early spliceosome assembly and splice site recognition”




Applications are invited for a PhD student position in the Beusch group at the Institute of Molecular Infection Biology at the University of Würzburg. Successful candidates will work in an interdisciplinary project aiming at understanding the initial steps in RNA splicing regulation and spliceosome assembly. Splicing is an essential step in post-transcriptional processing. Mutations that disrupt splicing have often deleterious consequences, causing a wide range of diseases from neuromuscular disorders to cancer. Our research group’s goal is to gain a detailed mechanistic understanding of splicing and its regulation within the cell to not only understand fundamental eukaryotic biology but also human disease. In particular, we focus on understanding how splice site choice occurs and how this interplays with the assembly of the spliceosome. The spliceosome is a highly complex molecular machine, which will assemble de novo from over 150 proteins and 5 small nuclear RNAs for each reaction that it catalyses. What fascinates us is not only how this assembly is regulated but how the spliceosome can handle its very diverse substrate pool. To do so, we use forward genetics (CRISPR-Cas9 base editing screens, CRISPR-Cas9 genome engineering) in combination with a wide range of technologies including RNA-seq approaches as well as molecular biology methods (e.g. proximity labelling, IP-MS) and biochemistry
A Master’s degree in life science and a strong background in either RNA biology or biochemistry.
Experience in molecular biology, tissue culture and cell line engineering, RNA-seq data analysis, and bioinformatics is welcome.
Good written and spoken English-language communication skills, and interest in working as part of an international team of researchers.
An interest in RNA biology, or desire to learn.
We welcome applications from suitably qualified people from all sections of the community regardless of race, gender or disability. The University aims to increase the proportion of female employees, therefore applications from qualified women are particularly welcome. Preference will be given to people with disabilities in the case of otherwise equal aptitude. The position is initially limited to 1 year with the possibility of extension upon good progress. Salary will be based on the pay scale for the public sector in Germany (TV-L).
For informal inquiries, please feel free to contact Dr. Irene Beusch ([email protected]).

Question:
You are searching for a BACHELOR project and are curious about unlocking the mysteries of pain? Be part of our cutting-edge research as we develop innovative models to study pain. Join us in generating organoids from induced pluripotent stem cells (iPSC) derived from patients suffering from neuropathic pain syndromes, and help uncover the underlying pathophysiology!

Some background:
In pain research, traditional animal models have long been used to study how sensory neurons transmit signals to the brain. However, with the development of organoid technology, there has been a shift from animal models to more human-related organoid systems. Utilizing an innovative organoid model of the somatosensory nervous system, we aim to advance the discovery of new druggable targets against neuropathic pain. Your tasks and learning opportunities during this BACHELOR project:


Cell culture: Culture of iPSCs and generation of neuro-mesodermal assembloids from patient-derived iPSCs

Expression analysis: Immunohistochemistry, fluorescence microscopy
You can take on this BACHELOR project, because:
You are eager to join our passionate research team and contribute to this project! You are a student of Life Sciences or related faculty. Preferably, you already have some experience in cell culture. We are a young and successful scientific TEAM in “Translational Somatosensorics” focusing on pain research and are located at the Department of Neurology, University Hospital Würzburg.

12 PhD positions (m/f/d)





part-time | temporary (max. until 06/2028) | starting October 2024
The Collaborative Research Centre 387 (SFB/CRC 387) is an interdisciplinary research network focusing on finding new approaches for the treatment of various tumor diseases through a better understanding of the role of the ubiquitin system in cancer. SFB/CRC 387 will start on October, 1 st 2024 and is funded for four years (with the option of extension for further 8 years). Leadership is spearheaded by the Technical University of Munich (TUM), however the SFB/CRC unites 38 PIs in seven research sites throughout Germany. Besides TUM, the Universities of Frankfurt (GU), Würzburg (JMU), Kiel (CAU), Mainz (JGU), the Helmholtz Munich and the Max Planck Institute of Biochemistry Munich are partners within the SFB/CRC. At all participating sites, the SFB/CRC 387 teams are well embedded in an outstanding scientific environment, offering access to state-of-the-art technologies, well-equipped laboratories, a vibrant scientific exchange and an internationally competitive scientific training program. An Integrated Research Training Group (IRTG) is dedicated to continue scientific education, host many network activities and support PhD candidates towards successful completion of their thesis.


CRC 387 offers



Training in topics and techniques relevant for your research
Graduate programs at each site, offering complementary training (e.g. scientific writing, research poster design)
Thesis Advisory Committee (TAC), supporting and guiding you in your scientific endeavors
Travel funds to visit conferences, laboratories and workshops
IRTG meetings with team building events
Attractive, interdisciplinary working environment supporting independence and mentoring at each site and within the whole CRC

very good / excellent scientific master degree in natural sciences
very good / excellent English skills
highly motivated and enthusiastic to join an interdisciplinary team
creativity, flexibility and a high degree of scientific curiosity

Employee discounts via various platforms with well-known companies and brands such as Adidas or AboutYou
Discounted or free tickets to sporting and cultural events such as the GOP Varieté theater
Discounted lunch in the canteen or cafeteria with a large selection of different dishes - also take away in a sustainable reusable ReCup container
Free use of the library through a branch of the Munich City Library located in the building
The option of leasing a job bike from Deutsche Dienstrad - also for private use
Working in the heart of Munich at Max-Weber-Platz with very good accessibility by public transport such as underground, S-Bahn or tram
Self-realisation through a varied and professionally challenging job with interdisciplinary cooperation between different departments of the MRI
Personal development and the opportunity to specialise through various training and further education opportunities

JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG, GERMANY
Institute for Molecular Infection Biology (IMIB)

PhD Student position (f/m/d)
“Regulation of early spliceosome assembly and splice site recognition”




Applications are invited for a PhD student position in the Beusch group at the Institute of Molecular Infection Biology at the University of Würzburg. Successful candidates will work in an interdisciplinary project aiming at understanding the initial steps in RNA splicing regulation and spliceosome assembly. Splicing is an essential step in post-transcriptional processing. Mutations that disrupt splicing have often deleterious consequences, causing a wide range of diseases from neuromuscular disorders to cancer. Our research group’s goal is to gain a detailed mechanistic understanding of splicing and its regulation within the cell to not only understand fundamental eukaryotic biology but also human disease. In particular, we focus on understanding how splice site choice occurs and how this interplays with the assembly of the spliceosome. The spliceosome is a highly complex molecular machine, which will assemble de novo from over 150 proteins and 5 small nuclear RNAs for each reaction that it catalyses. What fascinates us is not only how this assembly is regulated but how the spliceosome can handle its very diverse substrate pool. To do so, we use forward genetics (CRISPR-Cas9 base editing screens, CRISPR-Cas9 genome engineering) in combination with a wide range of technologies including RNA-seq approaches as well as molecular biology methods (e.g. proximity labelling, IP-MS) and biochemistry
A Master’s degree in life science and a strong background in either RNA biology or biochemistry.
Experience in molecular biology, tissue culture and cell line engineering, RNA-seq data analysis, and bioinformatics is welcome.
Good written and spoken English-language communication skills, and interest in working as part of an international team of researchers.
An interest in RNA biology, or desire to learn.
We welcome applications from suitably qualified people from all sections of the community regardless of race, gender or disability. The University aims to increase the proportion of female employees, therefore applications from qualified women are particularly welcome. Preference will be given to people with disabilities in the case of otherwise equal aptitude. The position is initially limited to 1 year with the possibility of extension upon good progress. Salary will be based on the pay scale for the public sector in Germany (TV-L).
For informal inquiries, please feel free to contact Dr. Irene Beusch ([email protected]).

12 PhD positions (m/f/d)





part-time | temporary (max. until 06/2028) | starting October 2024
The Collaborative Research Centre 387 (SFB/CRC 387) is an interdisciplinary research network focusing on finding new approaches for the treatment of various tumor diseases through a better understanding of the role of the ubiquitin system in cancer. SFB/CRC 387 will start on October, 1 st 2024 and is funded for four years (with the option of extension for further 8 years). Leadership is spearheaded by the Technical University of Munich (TUM), however the SFB/CRC unites 38 PIs in seven research sites throughout Germany. Besides TUM, the Universities of Frankfurt (GU), Würzburg (JMU), Kiel (CAU), Mainz (JGU), the Helmholtz Munich and the Max Planck Institute of Biochemistry Munich are partners within the SFB/CRC. At all participating sites, the SFB/CRC 387 teams are well embedded in an outstanding scientific environment, offering access to state-of-the-art technologies, well-equipped laboratories, a vibrant scientific exchange and an internationally competitive scientific training program. An Integrated Research Training Group (IRTG) is dedicated to continue scientific education, host many network activities and support PhD candidates towards successful completion of their thesis.


CRC 387 offers



Training in topics and techniques relevant for your research
Graduate programs at each site, offering complementary training (e.g. scientific writing, research poster design)
Thesis Advisory Committee (TAC), supporting and guiding you in your scientific endeavors
Travel funds to visit conferences, laboratories and workshops
IRTG meetings with team building events
Attractive, interdisciplinary working environment supporting independence and mentoring at each site and within the whole CRC

very good / excellent scientific master degree in natural sciences
very good / excellent English skills
highly motivated and enthusiastic to join an interdisciplinary team
creativity, flexibility and a high degree of scientific curiosity

Employee discounts via various platforms with well-known companies and brands such as Adidas or AboutYou
Discounted or free tickets to sporting and cultural events such as the GOP Varieté theater
Discounted lunch in the canteen or cafeteria with a large selection of different dishes - also take away in a sustainable reusable ReCup container
Free use of the library through a branch of the Munich City Library located in the building
The option of leasing a job bike from Deutsche Dienstrad - also for private use
Working in the heart of Munich at Max-Weber-Platz with very good accessibility by public transport such as underground, S-Bahn or tram
Self-realisation through a varied and professionally challenging job with interdisciplinary cooperation between different departments of the MRI
Personal development and the opportunity to specialise through various training and further education opportunities

Question:
You are searching for a BACHELOR project and are curious about unlocking the mysteries of pain? Be part of our cutting-edge research as we develop innovative models to study pain. Join us in generating organoids from induced pluripotent stem cells (iPSC) derived from patients suffering from neuropathic pain syndromes, and help uncover the underlying pathophysiology!

Some background:
In pain research, traditional animal models have long been used to study how sensory neurons transmit signals to the brain. However, with the development of organoid technology, there has been a shift from animal models to more human-related organoid systems. Utilizing an innovative organoid model of the somatosensory nervous system, we aim to advance the discovery of new druggable targets against neuropathic pain. Your tasks and learning opportunities during this BACHELOR project:


Cell culture: Culture of iPSCs and generation of neuro-mesodermal assembloids from patient-derived iPSCs

Expression analysis: Immunohistochemistry, fluorescence microscopy
You can take on this BACHELOR project, because:
You are eager to join our passionate research team and contribute to this project! You are a student of Life Sciences or related faculty. Preferably, you already have some experience in cell culture. We are a young and successful scientific TEAM in “Translational Somatosensorics” focusing on pain research and are located at the Department of Neurology, University Hospital Würzburg.

JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG, GERMANY
Institute for Molecular Infection Biology (IMIB)

PhD Student position (f/m/d)
“Regulation of early spliceosome assembly and splice site recognition”




Applications are invited for a PhD student position in the Beusch group at the Institute of Molecular Infection Biology at the University of Würzburg. Successful candidates will work in an interdisciplinary project aiming at understanding the initial steps in RNA splicing regulation and spliceosome assembly. Splicing is an essential step in post-transcriptional processing. Mutations that disrupt splicing have often deleterious consequences, causing a wide range of diseases from neuromuscular disorders to cancer. Our research group’s goal is to gain a detailed mechanistic understanding of splicing and its regulation within the cell to not only understand fundamental eukaryotic biology but also human disease. In particular, we focus on understanding how splice site choice occurs and how this interplays with the assembly of the spliceosome. The spliceosome is a highly complex molecular machine, which will assemble de novo from over 150 proteins and 5 small nuclear RNAs for each reaction that it catalyses. What fascinates us is not only how this assembly is regulated but how the spliceosome can handle its very diverse substrate pool. To do so, we use forward genetics (CRISPR-Cas9 base editing screens, CRISPR-Cas9 genome engineering) in combination with a wide range of technologies including RNA-seq approaches as well as molecular biology methods (e.g. proximity labelling, IP-MS) and biochemistry
A Master’s degree in life science and a strong background in either RNA biology or biochemistry.
Experience in molecular biology, tissue culture and cell line engineering, RNA-seq data analysis, and bioinformatics is welcome.
Good written and spoken English-language communication skills, and interest in working as part of an international team of researchers.
An interest in RNA biology, or desire to learn.
We welcome applications from suitably qualified people from all sections of the community regardless of race, gender or disability. The University aims to increase the proportion of female employees, therefore applications from qualified women are particularly welcome. Preference will be given to people with disabilities in the case of otherwise equal aptitude. The position is initially limited to 1 year with the possibility of extension upon good progress. Salary will be based on the pay scale for the public sector in Germany (TV-L).
For informal inquiries, please feel free to contact Dr. Irene Beusch ([email protected]).