PhD Student Biology - Molecular Biology (m/f/d)

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PhD Student Biology - Molecular Biology (m/f/d) in Würzburg

PhD Student Biology - Molecular Biology (m/f/d) in Würzburg, Deutschland

Stellenangebot als Biologe/Biologin in Würzburg , Bayern, Deutschland

Stellenbeschreibung | Jobbörse Arbeitsagentur

JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG, GERMANY
Institute for Molecular Infection Biology (IMIB)

PhD Student position (f/m/d)
“Regulation of early spliceosome assembly and splice site recognition”




Applications are invited for a PhD student position in the Beusch group at the Institute of Molecular Infection Biology at the University of Würzburg. Successful candidates will work in an interdisciplinary project aiming at understanding the initial steps in RNA splicing regulation and spliceosome assembly. Splicing is an essential step in post-transcriptional processing. Mutations that disrupt splicing have often deleterious consequences, causing a wide range of diseases from neuromuscular disorders to cancer. Our research group’s goal is to gain a detailed mechanistic understanding of splicing and its regulation within the cell to not only understand fundamental eukaryotic biology but also human disease. In particular, we focus on understanding how splice site choice occurs and how this interplays with the assembly of the spliceosome. The spliceosome is a highly complex molecular machine, which will assemble de novo from over 150 proteins and 5 small nuclear RNAs for each reaction that it catalyses. What fascinates us is not only how this assembly is regulated but how the spliceosome can handle its very diverse substrate pool. To do so, we use forward genetics (CRISPR-Cas9 base editing screens, CRISPR-Cas9 genome engineering) in combination with a wide range of technologies including RNA-seq approaches as well as molecular biology methods (e.g. proximity labelling, IP-MS) and biochemistry 
	A Master’s degree in life science and a strong background in either RNA biology or biochemistry.
	Experience in molecular biology, tissue culture and cell line engineering, RNA-seq data analysis, and bioinformatics is welcome.
	Good written and spoken English-language communication skills, and interest in working as part of an international team of researchers.
	An interest in RNA biology, or desire to learn.
 We welcome applications from suitably qualified people from all sections of the community regardless of race, gender or disability. The University aims to increase the proportion of female employees, therefore applications from qualified women are particularly welcome. Preference will be given to people with disabilities in the case of otherwise equal aptitude. The position is initially limited to 1 year with the possibility of extension upon good progress. Salary will be based on the pay scale for the public sector in Germany (TV-L).
For informal inquiries, please feel free to contact Dr. Irene Beusch ([email protected]).
Bundesagentur für Arbeit

Bundesagentur für Arbeit

Vollzeit
Bayern
Deutschland

Anfangsdatum

2024-10-01

Julius-Maximilians-Universität Würzburg

Am Hubland Süd 1

97074

Josef Schneider Str., 97080, Würzburg, Bayern, Deutschland

Julius-Maximilians-Universität Würzburg
Veröffentlicht:
2024-10-01
UID | BB-66fb76e062d92-66fb76e062d93
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Applications are invited for a PhD student position in the Beusch group at the Institute of Molecular Infection Biology at the University of Würzburg. Successful candidates will work in an interdisciplinary project aiming at understanding the initial steps in RNA splicing regulation and spliceosome assembly. Splicing is an essential step in post-transcriptional processing. Mutations that disrupt splicing have often deleterious consequences, causing a wide range of diseases from neuromuscular disorders to cancer. Our research group’s goal is to gain a detailed mechanistic understanding of splicing and its regulation within the cell to not only understand fundamental eukaryotic biology but also human disease. In particular, we focus on understanding how splice site choice occurs and how this interplays with the assembly of the spliceosome. The spliceosome is a highly complex molecular machine, which will assemble de novo from over 150 proteins and 5 small nuclear RNAs for each reaction that it catalyses. What fascinates us is not only how this assembly is regulated but how the spliceosome can handle its very diverse substrate pool. To do so, we use forward genetics (CRISPR-Cas9 base editing screens, CRISPR-Cas9 genome engineering) in combination with a wide range of technologies including RNA-seq approaches as well as molecular biology methods (e.g. proximity labelling, IP-MS) and biochemistry
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Good written and spoken English-language communication skills, and interest in working as part of an international team of researchers.
An interest in RNA biology, or desire to learn.
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Graduate programs at each site, offering complementary training (e.g. scientific writing, research poster design)
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Discounted or free tickets to sporting and cultural events such as the GOP Varieté theater
Discounted lunch in the canteen or cafeteria with a large selection of different dishes - also take away in a sustainable reusable ReCup container
Free use of the library through a branch of the Munich City Library located in the building
The option of leasing a job bike from Deutsche Dienstrad - also for private use
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A Master’s degree in life science and a strong background in either RNA biology or biochemistry.
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Good written and spoken English-language communication skills, and interest in working as part of an international team of researchers.
An interest in RNA biology, or desire to learn.
We welcome applications from suitably qualified people from all sections of the community regardless of race, gender or disability. The University aims to increase the proportion of female employees, therefore applications from qualified women are particularly welcome. Preference will be given to people with disabilities in the case of otherwise equal aptitude. The position is initially limited to 1 year with the possibility of extension upon good progress. Salary will be based on the pay scale for the public sector in Germany (TV-L).
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