Biologe (m/w/d) (Biologe/Biologin)

The Department of Dermatology, University Hospital Tübingen, in the working group of Prof. Dr. rer. nat. Birgit Schittek - Molecular Mechanisms of Melanoma Progression and Therapy Resistance -, the position of a

Research Associate

(PhD student or Postdoc) is to be filled from 1.6.2025 on or later.

The position is initially limited to 3 years. The scientific focus is a DFG funded project to investigate the role of CDKN1A/p21-dependent DNA damage response pathways in increasing the efficiency of targeted therapy in melanoma.
The tasks of the Research associate include the implementation of a wide variety of methods: molecular biology methods (qRT-PCR, RNA isolation, cloning, reporter gene analysis), biochemical methods (e.g. SDS-PAGE, Western blot, chromatography, proteomics), immunological methods (immunofluorescence, immunoprecipitation, ELISA , FACS) and cell biological methods (e.g. cell culture, 3D skin model, transfections, proliferation tests, apoptosis assays), mouse experiments using a melanoma tumor model. Applicants should be reliable and able to work in a team and have good practical experience in diverse cell biological, immunological and infectious research skills and with the methods mentioned above. Experience in cell culture and animal experiments is an advantage. In addition, we expect the results to be documented on the computer with the Windows programs Word, Excel, Power Point, GraphPad Prism. Applicants should already stay in a European country and should have a residence permit to work in Germany for the next three years.

PhD position (Dr. rer. nat.) in Biomedicine/Vascular Biology available from July 1st, 2025 at the Interfaculty Institute of Biochemistry (IFIB), University of Tübingen

The position is embedded in the Research Training Group “cGMP: From Bedside to Bench” (Graduiertenkolleg GRK 2381) funded by the Deutsche Forschungsgemeinschaft (DFG). This research consortium is investigating the role of the cellular signaling molecule cGMP in an interdisciplinary approach. We are looking for a highly motivated doctoral researcher to join project P4 “Crosstalk of cGMP and extracellular matrix signaling in atherosclerosis” (supervised by Dr. Susanne Feil). This project uses state-of-the-art transgenic mouse models and imaging technologies to determine how cardiovascular risk genes control the pathological behavior of vascular smooth muscle cells in atherosclerotic lesions. The PhD program supports an international internship in the laboratory of our collaborative partner at Tufts University in Boston, USA (Assist. Prof. Robert Blanton), who is also co-advisor of the doctoral thesis.

For details on the project and PhD training program, please see GRK 2381 website: https://uni-tuebingen.de/en/141767

Project-relevant publications:
doi: 10.1161/CIRCRESAHA.115.304634
doi: 10.1161/CIRCRESAHA.122.322296
doi: 10.1038/s41467-024-55687-9 A Master's degree in life sciences or equivalent is required for the position. Applicants should have a strong interest in cancer biology and in working at the interface of biochemistry, cell biology and biomedicine. Ideally, candidates have previous experience with mice and/or fluorescence microscopy. Initially a 3-year contract, salary level TV-L 13 / 65%

Das Universitätsklinikum Tübingen ist ein führendes Zentrum der deutschen Hochschulmedizin. Jährlich werden etwa 75.000 Patientinnen und Patienten stationär und ca. 380.000 ambulant behandelt. Mit rund 11.000 Mitarbeiterinnen und Mitarbeitern ist es der größte Arbeitgeber der Region. Die Qualität der Krankenversorgung ist mit dem Gütesiegel der KTQ zertifiziert.

Wir suchen für die Universitätsklinik für Kinder- und Jugendmedizin zum nächstmöglichen Zeitpunkt Ihre Unterstützung als

Leitung grundlagenwissenschaftliches Forschungslabor (w/m/d)

in der Abteilung für Kinderchirurgie und Kinderurologie in Vollzeit und unbefristet.

Die Abteilung für Kinderchirurgie und Kinderurologie des Universitätsklinikums Tübingen (Ärztlicher Direktor Prof. Dr. J. Fuchs) mit dem klinischen und wissenschaftlichen Schwerpunkt der Kinderonkologie ist eines der führenden kinderchirurgischen / kinderurologischen Zentren Deutschlands. Unsere Abteilung ist eines der deutschen Zentren für Gallengangsatresien und koordiniert das europäische Register für diese schwerwiegende Lebererkrankung. Die chirurgische Behandlung und die Forschung im kinderonkologischen und -hepatologischen Bereich geschieht an unserer Klinik in enger Zusammenarbeit mit der Abteilung Pädiatrische Onkologie mit Nephrologie, Hepatologie und Gastroenterologie (Ärztlicher Direktor Prof. Dr. J. Schulte).

Leitung eines etablierten, molekularbiologischen Forschungslabors mit entsprechender personeller und apparativer Ausstattung
Koordination der zentralen, interdisziplinären Forschungseinheit der gesamten Kinderklinik
Eigenständige Planung und Entwicklung innovativer Forschungsprojekte auf dem Gebiet der pädiatrisch-onkologischen Forschung
Akquise von Drittmitteln
Kritische Analyse und Kommunikation der Forschungsergebnisse durch Verfassen von wissenschaftlichen Publikationen
Präsentation der Ergebnisse auf internen Labortreffen und externen Konferenzen auf nationaler und internationaler Ebene
Sie sind als Teil des Teams in der Abteilung für Kinderchirurgie und Kinderurologie tätig und arbeiten eng mit dem Forschungs-Konsortium der pädiatrischen Onkologie und Hepatologie zusammen
Anwerbung und Betreuung von Studierenden sowie von medizinischen und naturwissenschaftlichen Doktorandinnen / Doktoranden

Studium der Biologie, molekularen Medizin, Biochemie oder ein vergleichbares naturwissenschaftliches Studium mit überdurchschnittlichem Abschluss und einer Promotion
Fundierte Kenntnisse in der Durchführung von molekularbiologischen Methoden, Erfahrung mit primärer Zellkulturmethoden, Imaging und Durchflusszytometrie
Erfahrung im Umgang mit Versuchstieren sowie mit der Auswertung und Analyse großer Sequenzier-Datensets erwünscht, aber nicht zwingend erforderlich
Routine in der Auswertung und Präsentation wissenschaftlicher Ergebnisse
Arbeiten mit EDV-Standardanwendungen ist für Sie selbstverständlich
Sichere Kommunikation in englischer Sprache
Erfahrung in der Antragstellung zum Einwerben von Drittmitteln
Strukturierte und leistungsorientierte Arbeitsweise
Teamfähigkeit und soziale Kompetenz

Die Möglichkeit zur Habilitation
Mitarbeit im vielseitigen Umfeld eines modernen Universitätsklinikums, welches neben der Krankenversorgung zusätzlich die medizinische Forschung und Lehre fokussiert
Zukunftssicherer Arbeitsplatz und Standort sowie eine attraktive Vergütung einschließlich betrieblicher Altersversorgung (VBL) bei gleichzeitig möglichst flexiblen Arbeitszeitregelungen
Zuschuss zum Ticket für den öffentlichen Nahverkehr und attraktive Nachlässe auf unseren Angebotsplattformen für Mitarbeitende
Strukturierte Onboarding-Phase, klinikumseigene Akademie zum Ausbau der Fach-, Sozial- und Methodenkompetenz
Gesundheitsvorsorge durch vielfältige Sportangebote

Wir wenden den Tarifvertrag für den öffentlichen Dienst der Länder (TV-L) an, Schwerbehinderte werden bei gleicher Eignung vorrangig berücksichtigt. Vorstellungskosten können leider nicht übernommen werde...

Das Universitätsklinikum Tübingen ist ein führendes Zentrum der deutschen Hochschulmedizin. Jährlich werden etwa 75.000 Patientinnen und Patienten stationär und ca. 380.000 ambulant behandelt. Mit rund 11.000 Mitarbeiterinnen und Mitarbeitern ist es der größte Arbeitgeber der Region. Die Qualität der Krankenversorgung ist mit dem Gütesiegel der KTQ zertifiziert.

Wir suchen für die Universitätsklinik für Kinder- und Jugendmedizin zum 01.04.2025 Ihre Unterstützung als

Wissenschaftliche/-r Mitarbeiter/-in (PostDoc) für Translationale Forschung (w/m/d)

im Bereich Immunologie in der Abteilung I (Hämatologie, Onkologie, Gastroenterologie, Nephrologie und Rheumatologie) in Vollzeit und befristet zunächst auf 3 Jahre mit der Option auf Verlängerung.

Die Abteilung Kinderheilkunde I (Direktor: Prof. Dr. med. Johannes Schulte) verfolgt das Ziel, die Prognose schwerer maligner Erkrankungen im Kindes- und Jugendaltern nachhaltig zu verbessern. Vor allem im Bereich Hämatologie und Onkologie ist es Ziel, innovative Therapien wie patientenindividuelle Anti-Tumor Peptidvakzinen in die Standardtherapie zu implementieren. Die derzeit laufende PERVISION Studie, durchgeführt bei Patientinnen / Patienten mit metastierten, fusionsgetriebenen Sarkomen (DKTK-finanziert, klinische Leitung Prof. Dr. Martin Ebinger, Co-Leiter Weichgewebssarkom Studiengruppe der GPOH) untersucht, ob bei diesen Patientinnen / Patienten nach Therapie und Erreichen eine Remission mit einer Peptivakzinierung mit Fusionspeptid die Chancen auf dauerhafte Heilung verbessert werden können.

Die AG Prof. Dr. Karin Schilbach arbeitet daran, T-Zellantworten gegen sarkomspezifische Epitope, insbesondere gegen das Fusionspeptid molekular zu charakterisieren, um über T-Zellzeptorheterodimer-Identifikation potenziell die Herstellung sarkomspezifischer T-Zellen zu ermöglichen. Diese Arbeiten sollen fortgeführt werden.

Aufbau und Leitung einer eigenen Forschungsgruppe mit Betreuung von Doktorandinnen / Doktoranden und Masterstudentinnen/-studenten sowie die Einwerbung von Drittmitteln
Entwicklung eines NGS-basierten Immunmonitorings zur Analyse innovativer Immuntherapien, einschließlich des Immunmonitorings für das PerVision clinical trial, patientenindividueller anti-Tumor-Peptidvakzinen und des Nachweises antitumoraler T-Zellantworten nach immuntherapeutisch induzierter Stromarevision
Etablierung einer Bank für epitopspezifische TCRs definierter HLA-Restiktion zur gezielten Therapie uniformer Tumorepitope
Funktionale Validierung identifizierter TCRs in vitro und ihre Translation in die klinische Anwendung
Enge Kooperation mit weiteren internen und externen AGs, u. a. zur Entwicklung innovativer Therapiekonzepte
Wissenschaftliche Veröffentlichungen in renommierten Fachzeitschriften
Beteiligung an der Ausbildung von Studierenden und Nachwuchswissenschaftlerinnen/-wissenschaftlern mit der Möglichkeit zur Habilitation und eigener wissenschaftlicher Karriereentwicklung
Bearbeitung von Multi-Omic-Analysen (Transkription, Phänotyp) auf Bulk- und Einzellebene zur Weiterentwicklung der Forschungskapazitäten im Bereich der Immuntherapie

Abgeschlossenes Master- und Promotionsstudium
Engagement und Expertise in den Bereichen Medizinwissenschaften, Zell- und Molekularbiologie sowie Immunologie
Erfahrung mit zell- und molekularbiologischen Techniken
Kenntnisse in Bioinformatik und statistischer Analyse, analytisches Denken, Verantwortungsbewusstsein und Teamgeist
Gute Englischkenntnisse
Selbstständige und präzise Arbeitsweise

Mitarbeit im vielseitigen Umfeld eines modernen Universitätsklinikums, welches neben der Krankenversorgung zusätzlich die medizinische Forschung und Lehre fokussiert
Zukunftssicherer Arbeitsplatz und Standort sowie eine attraktive Vergütung einschließlich betrieblicher Altersversorgung (VBL) bei gleichzeitig möglichst flexiblen Arbeitszeitregelungen
Zuschuss zum Ticket für den öffentlichen Nahverkehr und attraktive Nachlässe auf unseren A...

Design. Progress. Together.

CureVac SE is a global biopharmaceutical company researching and developing novel drugs based on the natural molecule Messenger RNA (mRNA). Our focus is on prophylactic vaccines, innovative cancer immunotherapies and protein-based therapies. Currently, all RNA people are striving to achieve our main goal: To bring multiple best-in-class mRNA drugs to market.

To strengthen our team in Tübingen near Stuttgart, we are currently looking to recruit a

(Senior) Scientist (f/m/d) Infectious Disease Discovery & Research

The position will involve working as part of an interdisciplinary team with the aim of developing the therapeutic potential of RNA. Within this remit, you will focus on addressing formulation issues related to this class of medicines.
Lead and conduct research to develop and evaluate mRNA-based vaccines against infectious pathogens with a focus on optimizing vaccine performance and longevity of responses
Design, execute, interpret and document in vitro and in vivo experiments to characterize the immunogenicity of mRNA vaccines
Collaborate with cross-functional teams to integrate findings into the broader vaccine development pipeline
Coordinate collaborations with industrial and academic partners
Stay current with the latest scientific literature and technological advancements in the field of mRNA vaccines
Present and discuss data with diverse stakeholders and at scientific meetings
Prepare and review experimental data and reports for scientific publication and regulatory submission

PhD in Life Sciences with relevant postdoctoral experience in academic, pharmaceutical or biotechnology settings
Proven experience in immunology, preferably in the context of vaccine development
Strong background in immunological assays and techniques
FELASA B qualification preferable
Proactive, structured, efficient way of working in a dynamic environment
Excellent problem-solving skills and the ability to work independently and collaboratively
A track record of scientific publications in peer-reviewed journals is preferred
Strong team spirit, communication and presentation skills
Fluency in English; German is a plus
We offer you a challenging and varied opportunity with an innovative and dynamic company that is expanding.
With much passion and sense of responsibility, we work together on the medical revolution. We pride ourselves on maintaining an honest and trusting relationship with each other which is characterized by openness to new ideas and continuous progress. Mutual respect, reliability and personal initiative are self-evident for us.

Design. Progress. Together.

CureVac SE is a global biopharmaceutical company researching and developing novel drugs based on the natural molecule Messenger RNA (mRNA). Our focus is on prophylactic vaccines, innovative cancer immunotherapies and protein-based therapies. Currently, all RNA people are striving to achieve our main goal: To bring multiple best-in-class mRNA drugs to market.

To strengthen our team in Tübingen near Stuttgart or Wiesbaden, we are currently looking to recruit a

Project Manager (f/m/d) Oncology
Manage and support a cross-functional, geographically dispersed and matrixed product development project team in the field of oncology
Take care of the operational execution of projects assigned to the project team
Set measurable goals for the project in alignment with team members and program leadership
Develop implementation plans utilizing program/project management techniques and other applicable tools
Ensure and maintain quality and accuracy of planning information and forecasts in enterprise planning systems
Provide schedules, timelines, milestones, and performance reports
Track progress towards accomplishing program milestones and deliverables in the respective management reporting tools and templates
Drive the preparation for stage gate transitions of projects within a program
Organize, facilitate, and document team meetings and workshops
Ensure an appropriate level of stakeholder communication

University degree in Science / Medicine, Business Administration or equivalent, MBA or a similar academic qualification
Project Management track record in the field of pharmaceuticals / biotechnology / healthcare
PMP or comparable project management certification
Experience in managing global interdisciplinary and multicultural project/program teams in a matrix organization
Motivating leadership behavior in a challenging status quo and the ability to drive transformation/influence the development of complex teams with a varying maturity status
Ability to handle multiple topics and responsibilities simultaneously
Experience in collaboration projects beneficial
Knowledge of working in a stage gate framework is a plus
Profound IT skills (Microsoft365, MS Project, risk management tools)
Business fluency in English, German skills are a plus
We offer you a challenging and varied opportunity with an innovative and dynamic company that is expanding.
With much passion and sense of responsibility, we work together on the medical revolution. We pride ourselves on maintaining an honest and trusting relationship with each other which is characterized by openness to new ideas and continuous progress. Mutual respect, reliability and personal initiative are self-evident for us.

Design. Progress. Together.

CureVac SE is a global biopharmaceutical company researching and developing novel drugs based on the natural molecule Messenger RNA (mRNA). Our focus is on prophylactic vaccines, innovative cancer immunotherapies and protein-based therapies. Currently, all RNA people are striving to achieve our main goal: To bring multiple best-in-class mRNA drugs to market.

To strengthen our team in Tübingen near Stuttgart or Wiesbaden, we are currently looking to recruit a

Project Manager (f/m/d) Oncology
Manage and support a cross-functional, geographically dispersed and matrixed product development project team in the field of oncology
Take care of the operational execution of projects assigned to the project team
Set measurable goals for the project in alignment with team members and program leadership
Develop implementation plans utilizing program/project management techniques and other applicable tools
Ensure and maintain quality and accuracy of planning information and forecasts in enterprise planning systems
Provide schedules, timelines, milestones, and performance reports
Track progress towards accomplishing program milestones and deliverables in the respective management reporting tools and templates
Drive the preparation for stage gate transitions of projects within a program
Organize, facilitate, and document team meetings and workshops
Ensure an appropriate level of stakeholder communication

University degree in Science / Medicine, Business Administration or equivalent, MBA or a similar academic qualification
Project Management track record in the field of pharmaceuticals / biotechnology / healthcare
PMP or comparable project management certification
Experience in managing global interdisciplinary and multicultural project/program teams in a matrix organization
Motivating leadership behavior in a challenging status quo and the ability to drive transformation/influence the development of complex teams with a varying maturity status
Ability to handle multiple topics and responsibilities simultaneously
Experience in collaboration projects beneficial
Knowledge of working in a stage gate framework is a plus
Profound IT skills (Microsoft365, MS Project, risk management tools)
Business fluency in English, German skills are a plus
We offer you a challenging and varied opportunity with an innovative and dynamic company that is expanding.
With much passion and sense of responsibility, we work together on the medical revolution. We pride ourselves on maintaining an honest and trusting relationship with each other which is characterized by openness to new ideas and continuous progress. Mutual respect, reliability and personal initiative are self-evident for us.

Immatics combines the discovery of true targets for cancer immunotherapies with the development of the right T cell receptors with the goal of enabling a robust and specific T cell response against these targets. This deep know-how is the foundation for our pipeline of Adoptive Cell Therapies and TCR Bispecifics as well as our partnerships with global leaders in the pharmaceutical industry. Operating from Tuebingen, Munich and Houston, we are committed to delivering the power of T cells and to unlocking new avenues for patients in their fight against cancer. For more detailed information, visit www.immatics.com.

Senior Manager Clinical Quality Assurance*

Overview
We are currently seeking a Senior Manager Clinical Quality Assurance* to strengthen our Clinical Quality Assurance (CQA) department. You will work remote (Germany) in an interdisciplinary environment with colleagues from Germany and the US. Your analytical reasoning and action-oriented style as well as your organization and communication skills will contribute to the team's success.
Your main responsibilities will include but are not limited to the following tasks:

Support of the implementation and maintenance of clinical QA processes and systems
Maintenance of the clinical eQMS component including the definition, generation, and interpretation of quality metrics and trending reporting
Creation or review and approval of quality related documents, including e.g., QMS SOPs, working instructions, and respective quality documentation related to clinical trial management activities
CQA Quality Management counterpart for the operational clinical functions; provision of guidance and support to clinical functions for e.g., protocol and process deviation management, change controls, root cause analyses, CAPA definitions for deviations/ audits and inspection observations, vendor selection and oversight aspects as well as support for the related eQMS deliverables
Support of the implementation and the maintenance of inspection readiness concepts and the preparation, hosting, and follow up of regulatory inspections
Organization and conduct of quality related trainings to colleagues

You hold a University degree in natural sciences, engineering, quality management, or a related field, and have gained 5+ years of experience in working for life sciences companies in a clinical quality management function. Experience in clinical trial quality management as well as in-depth knowledge of GCP regulatory requirements is expected. You are comfortable working at a global level in a highly matrixed environment. We expect excellent interdisciplinary and intercultural communication skills in English and preferably German.

A high degree of initiative, analytical reasoning and strong problem solving skills are required. You approach tasks in a structured, reliable and foresighted manner, combined with an elevated level of individual responsibility, enthusiasm and strong social skills.

We are a committed and inspired team and cherish the collegial, highly motivated, and family-friendly atmosphere within Immatics. Our culture allows for a high level of originality, independent thinking, and initiative. We believe in supporting our employees' professional and social skills: We enable them to join conferences and trainings as well as to enjoy our Immatics benefits - e.g., job bike, job ticket, Health Programs, childcare benefits, relocation allowance, Company summer and winter events.

Notice

*We value diversity and inclusion. Immatics N.V. and all Immatics subsidiaries are equal opportunity employers that evaluate qualified applicants without regard to ethnicity, color, national origin, religion, gender, age, marital status, disability, veteran status, romantic orientation, gender identity, or other characteristics protected by law.