Leitung Core Facility Bioinformatik & Statistik (m/w/d) (Bioinformatiker/in)

“Research for a life without cancer" is our mission at the German Cancer Research Center. We investigate how cancer develops, identify cancer risk factors and look for new cancer prevention strategies. We develop new methods with which tumors can be diagnosed more precisely and cancer patients can be treated more successfully. Every contribution counts – whether in research, administration or infrastructure. This is what makes our daily work so meaningful and exciting.

Together with university partners at seven renowned partner sites, we have established the German Cancer Consortium (DKTK).

The Department of Translational Cancer Research and the Institute of Experimental Cancer Therapy at the DKTK partner site Munich is offering for as soon as possible 2 PhD Student Positions in Pancreatic Cancer Immunology and Computational Biology.

We are deploying advanced in vitro and in vivo model systems, genetic perturbations and single cell technologies with spatial readouts to study the distinct routes of tumor evolution and modes of immunosuppression we identified in our previous work in subtypes of pancreatic cancer (e.g., Nat Commun. 2023 14:2642 and 14:1201; Nature Cancer 2022 3:318-336, Cancer Discovery 2021 11:3158-3177, Nature 2018 554:62-68; Nat. Rev. Cancer 2017 17:239-253; Nat. Commun. 2016, 7:10770; Nat Med. 2014, 20:1340-7). During the past decade, our lab has generated a comprehensive resource of pancreatic primary tumors and primary cell cultures. Multiple NGS methods and biological readouts have been conducted to decipher the molecular makeup and phenotypes of these tumors. The advertised projects focus on (1) unraveling targetable nodes of the cancer-immune niche and its impact on treatment response and resistance, (2) understanding the contribution of cancer associated fibroblasts towards immunosuppression, and (3) developing computational single cell and spatial transcriptomics pipelines to investigate tumor subtype specific genetic interactions in close collaboration with the Theis lab at Helmholtz Center Munich.

We are an enthusiastic and international team and offer intensive training and mentoring.

Your Tasks

The successful candidates will have the opportunity to:

- Gain important insights into clinically relevant aspects of cancer development and therapy
- Perform state-of-the-art in vivo experiments and large-scale drug and genetic screens
- Learn and apply a wide spectrum of genetic, molecular and cell biology, biochemical as well as immunological and bioinformatics techniques to study translational aspects of cancer (e.g. Cre/loxP and Flp/FRT based dual- and triple recombinase systems, organoid culture, orthotopic transplantations of cells/organoids, CRISPR/Cas9, molecular in vivo imaging, quantitative proteomics/phosphoproteomics, multiple transcriptomics and genomics approaches, single cell sequencing, histocytometry)
- Set up bioinformatics platforms and develop computational pipelines for the analysis of bulk and single cell RNA-sequencing, DNA-sequencing datasets and proteomics
- Integrate these datasets with molecular (WES, WGBS, lcWGS, ChIPseq, ATACseq), phenotypic (e.g. histology), drug screening and clinical information
- Interact within a diverse and multidisciplinary environment of biologists, clinicians, computational scientists and mathematicians within the TranslaTUM.

Your Profile

We are looking for exceptional self-motivated bright individuals with a Diploma or Master’s degree in bioinformatics, biochemistry, biology, molecular/translational medicine or related subjects. Previous exposure to and experience with basic biochemical and molecular biology techniques, proteomics or bioinformatics as well as interests in molecular aspects of cancer research are essential. Due to the interdisciplinary framework and close collaboration between wet-lab and computational scientists, good communicative skills in English are essential. German language skills are not required.

We Offer

- Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level
- Access to international research networks
- Doctoral salary with the usual social benefits
- 30 days of vacation per year
- Flexible working hours
- Possibility of part-time work
- Family-friendly working environment
- Sustainable travel to work: subsidized Germany job ticket
- Unleash your full potential: targeted training and mentoring through the DKFZ International PhD Program and DKFZ Career Service
- Our Corporate Health Management Program offers a holistic approach to your well-being

Are you interested?

Then become part of the DKFZ and join us in contributing to a life without cancer!

Contact:

Prof. Dr. Dieter Saur
Phone: +49 89 4140 9130

​Duration: The positions are limited to 3 years. An extension is possible.

Application Deadline: 03.05.2025

Applications by e-mail cannot be accepted.

Please also note that we cannot return applications submitted by post.

We are convinced that an innovative research and working environment thrives on the diversity of its employees. Therefore, we welcome applications from talented people, regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical ability, religion and age. People with severe disabilities are given preference if they have the same aptitude.

Notice: We are subject to the regulations of the Infection Protection Act (IfSG). Therefore, all our employees must provide proof of immunity against measles.

“Research for a life without cancer" is our mission at the German Cancer Research Center. We investigate how cancer develops, identify cancer risk factors and look for new cancer prevention strategies. We develop new methods with which tumors can be diagnosed more precisely and cancer patients can be treated more successfully. Every contribution counts – whether in research, administration or infrastructure. This is what makes our daily work so meaningful and exciting.

Together with university partners at seven renowned partner sites, we have established the German Cancer Consortium (DKTK).

The Department of Translational Cancer Research and the Institute of Experimental Cancer Therapy at the DKTK partner site Munich is offering for as soon as possible 2 Postdoc Positions in Pancreatic Cancer Immunology and Computational Biology.

We are deploying advanced in vitro and in vivo model systems, genetic perturbations and single cell technologies with spatial readouts to study the distinct routes of tumor evolution and modes of immunosuppression we identified in our previous work in subtypes of pancreatic cancer (e.g., Nat Commun. 2023 14:2642 and 14:1201; Nature Cancer 2022 3:318-336, Cancer Discovery 2021 11:3158-3177, Nature 2018 554:62-68; Nat. Rev. Cancer 2017 17:239-253; Nat. Commun. 2016, 7:10770; Nat Med. 2014, 20:1340-7). During the past decade, our lab has generated a comprehensive resource of pancreatic primary tumors and primary cell cultures. Multiple NGS methods and biological readouts have been conducted to decipher the molecular makeup and phenotypes of these tumors. The advertised projects focus on (1) unraveling targetable nodes of the cancer-immune niche and its impact on treatment response and resistance, (2) understanding the contribution of cancer associated fibroblasts towards immunosuppression, and (3) developing computational single cell and spatial transcriptomics pipelines to investigate tumor subtype specific genetic interactions in close collaboration with the Theis lab at Helmholtz Center Munich.

We are an enthusiastic and international team and offer intensive training and mentoring.

The Department of Translational Cancer Research and the Institute of Experimental Cancer Therapy at the DKTK partner site Munich is seeking two postdocs to join the group as soon as possible.

Your Tasks

The successful candidates will have the opportunity to:

- Gain important insights into clinically relevant aspects of cancer development and therapy
- Perform state-of-the-art in vivo experiments and large-scale drug and genetic screens
- Learn and apply a wide spectrum of genetic, molecular and cell biology, biochemical as well as immunological and bioinformatics techniques to study translational aspects of cancer (e.g. Cre/loxP and Flp/FRT based dual- and triple recombinase systems, organoid culture, orthotopic transplantations of cells/organoids, CRISPR/Cas9, molecular in vivo imaging, quantitative proteomics/phosphoproteomics, multiple transcriptomics and genomics approaches, single cell sequencing, histocytometry)
- Set up bioinformatics platforms and develop computational pipelines for the analysis of bulk and single cell RNA-sequencing, DNA-sequencing datasets and proteomics
- Integrate these datasets with molecular (WES, WGBS, lcWGS, ChIPseq, ATACseq), phenotypic (e.g. histology), drug screening and clinical information
- Interact within a diverse and multidisciplinary environment of biologists, clinicians, computational scientists and mathematicians within the TranslaTUM.

Your Profile

We are looking for exceptional self-motivated bright individuals with a Diploma or Master’s degree in bioinformatics, biochemistry, biology, molecular/translational medicine or related subjects. Previous exposure to and experience with basic biochemical and molecular biology techniques, proteomics or bioinformatics as well as interests in molecular aspects of cancer research are essential. Due to the interdisciplinary framework and close collaboration between wet-lab and computational scientists, good communicative skills in English are essential. German language skills are not required.

Interested candidates should send one pdf file with a CV, cover letter, certificates, and letters of recommendation.

We Offer

- Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level
- Remuneration according to TV-L incl. occupational pension plan and capital-forming payments
- 30 days of vacation per year
- Flexible working hours
- Possibility of part-time work
- Family-friendly working environment
- Sustainable travel to work: subsidized Germany job ticket
- Our Corporate Health Management Program offers a holistic approach to your well-being
- Develop your full potential: access to the DKFZ International Postdoc Program and DKFZ Career Service with targeted offers for your personal development to further develop your talents

Are you interested?

Then become part of the DKFZ and join us in contributing to a life without cancer!

Contact:

Prof. Dr. Dieter Saur
Phone: +49 89 4140 9130

​Duration: The positions are initially limited to 2 years with the possibility of prolongation.

Application Deadline: 03.05.2025

Applications by e-mail cannot be accepted.

Please also note that we cannot return applications submitted by post.

We are convinced that an innovative research and working environment thrives on the diversity of its employees. Therefore, we welcome applications from talented people, regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical ability, religion and age. People with severe disabilities are given preference if they have the same aptitude.

Notice: We are subject to the regulations of the Infection Protection Act (IfSG). Therefore, all our employees must provide proof of immunity against measles.

Bioinformatiker:in in Pflanzengenomik (m/w/d)

102731

Vollzeit
39 Std./Woche

Neuherberg bei München

Anteilig Home Office möglich

Bei Helmholtz Munich entwickeln wir bahnbrechende Lösungen für eine gesündere
Gesellschaft in einer sich schnell verändernden Welt. Wir glauben, dass
vielfältige Perspektiven Innovationen vorantreiben. Durch starke Netzwerke
beschleunigen wir den Transfer neuer Ideen aus dem Labor in die Praxis, um
Leben zu verbessern.

Die Forschungseinheit Genomik und Systembiologie pflanzlicher Genome (PGSB)
konzentriert sich auf die Analyse von pflanzengenomischen Daten mithilfe
bioinformatischer Methoden. Unsere Mission besteht darin, Möglichkeiten für
eine nachhaltige Nutzung von Pflanzen zu entwickeln und zu verstehen, wie sich
der Klimawandel auf Nutzpflanzen, die Lebensmittelsicherheit und die
menschliche Gesundheit auswirkt.

Deine Aufgaben

- Selbstständige Planung und Durchführung wissenschaftlicher Projekte im
Bereich der Pflanzengenomik
- Organisation, Durchführung und Auswertung von bioinformatischen Daten
- Anleitung von Doktorand:innen, Bachelor-/Masterstudent:innen und
technischen Hilfskräften bei der Durchführung von Experimenten sowie der
Erstellung von Arbeitsberichten, Doktorarbeiten, Seminarvorträgen und
Posterpräsentationen
- Verfassen von Manuskripten und Anträgen auf Forschungsförderung
- Statistische Analyse der komplexen pflanzengenomischen Daten
- Präsentation von Projektergebnissen und Erstellung von Veröffentlichungen

Dein Profil

- Abgeschlossenes Universitätsstudium im Bereich Bioinformatik, Biologie oder
verwandter Disziplinen mit Promotion
- Tiefgehende Kenntnisse in der Planung und Durchführung von Feld- und
Gewächshaus-Experimenten zur Erfassung agronomischer und pflanzenbiologischer
Merkmale
- Gute Kenntnisse im Bereich der Genomik, Genetik und Proteomik, sowie in
statistischer und bioinformatischer Auswertung von experimentellen
Proteomikdaten
- Umfangreiche Erfahrung in der genomischen Analyse von komplexen Daten aus
den Modellorganismen Mais und/oder Gerste sowie in der Analyse pflanzlicher
Pan-Genome
- Programmierkenntnisse in mindestens einer Sprache (Phyton, R, Perl)

Bei Vorliegen der Voraussetzungen ist eine Eingruppierung bis E 13 möglich.
Sozialleistungen richten sich nach dem Tarifvertrag für den öffentlichen Dienst
(Bund). Die Stelle ist (zunächst) auf 1 Jahr befristet, die Möglichkeit einer
längerfristigen Perspektive besteht.

Geschäftsführer Matthias Tschöp und Mike Frieser:

„Wir glauben, dass Vielfalt der Schlüssel zu bahnbrechender Forschung und
innovativen Lösungen ist. Unsere flexiblen Arbeitszeitmodelle und die
Möglichkeit zum mobilen Arbeiten schaffen ein geeignetes Umfeld für die
Vereinbarkeit von Beruf und Privatleben. Für uns ist der Beitrag zu einer
gesünderen Gesellschaft an einem so inspirierenden Arbeitsplatz wirklich
wertvoll.“

Lerne uns kennen

Benefits

- Wissenschaftliche Ressourcen Hochmoderne Infrastruktur und Core Facilities
- Potenzial fördern vielfältiges Inhouse-Angebot für zielgerichtete
Weiterbildungsmöglichkeiten
- Gesundheitsangebot Sport, Betriebsarzt, mentale Gesundheit
- Familienfreundlich KITA, Ferienbetreuung, Elder Care
- Karriere beschleunigen Postdoc-Programm, wissenschaftliche Trainings und
Career Center mit maßgeschneiderten Angeboten
- Leadership stärken vielfältige, maßgeschneiderte Entwicklungsprogramme für
Führungskräfte

Interesse geweckt?

Falls noch Fragen offen sind, hilft gerne Hr. Dr. Manuel Spannagl,
+498931873948, weiter.

Unser Recruiting erfolgt dezentral - deine Bewerbung wird direkt von der
Fachabteilung gesichtet, in der du möglicherweise künftig arbeiten wirst.

Leitung Core Facility Bioinformatik & Statistik (m/w/d)

102718

Vollzeit
39 Std./Woche

Neuherberg bei München

Anteilig Home Office möglich

Bei Helmholtz Munich entwickeln wir bahnbrechende Lösungen für eine gesündere
Gesellschaft in einer sich schnell verändernden Welt. Wir glauben, dass
vielfältige Perspektiven Innovationen vorantreiben. Durch starke Netzwerke
beschleunigen wir den Transfer neuer Ideen aus dem Labor in die Praxis, um
Leben zu verbessern.

Helmholtz Munich betreibt acht Core Facilitieszur Unterstützung interner
Forschungsgruppen sowie externer Kunden. Wir bringen Bioinformatik und
Biostatistik unter einem Dach zusammen und suchen eine erfahrene Leitung für
diese Core Facility, um unsere Unterstützung im Bereich der Datenanalyse weiter
zu verbessern.

Als Leitung der Core Facility Bioinformatik und Statistikführst du ein
multidisziplinäres Team, das Forschende bei computergestützten und
statistischen Analysen in den Bereichen Biomedizin und Biowissenschaften
unterstützt. Du leitest und entwickelst die Core Facility strategisch,
entwickelst analytische Pipelines und statistische Beratungsangebote, berätst
bei der Versuchsplanung und führst Schulungen in bioinformatischen und
biostatistischen Methoden durch. Die Position erfordert Fachwissen in
Bioinformatik und -statistik, strategische Weitsicht, tiefes Engagement und die
Fähigkeit und Bereitschaft zu exzellentem Service für die Wissenschaft.

Wenn du auf der Suche nach einer spannenden Führungsposition bist, in der du
mit Datensätzen von modernsten Technologien in den Bereichen Genomik,
Proteomik, Metabolomik, Bildgebungsdaten, KI-gesteuerter Analytik und
Präzisionsmedizin arbeitest, dann könnte dies die richtige Stelle für dich
sein. Wir bieten die Möglichkeit, in einer internationalen
Forschungseinrichtung von Weltrang mit Biolog:innen, Kliniker:innen,
Datenwissenschaftler:innen und IT-Spezialist:innen zusammenzuarbeiten.

Deine Aufgaben

- Personalführung & strategische Entwicklung: Leitung und Weiterentwicklung
eines multidisziplinären Teams aus Bioinformatiker:innen und Statistiker:innen.
Entwicklung und Umsetzung der strategischen Ausrichtung der Core Facility im
Einklang mit den Forschungszielen von Helmholtz Munich.
- Datenanalyse & Methodenintegration: Entwicklung und Bereitstellung von
analytischen Pipelines für Genomics, Proteomics, Metabolomics, Spatial Omics
und andere Omics-Daten. Sicherstellung von Best Practices in Datenverarbeitung,
-integration und -visualisierung. Evaluierung und Implementierung von
KI-basierten Tools für die bioinformatische Analyse.
- Statistische Beratung: Unterstützung von Forschenden bei experimentellem
Design und Datenanalysen. Enge Zusammenarbeit mit internen und externen
Wissenschaftler:innen zur Unterstützung von Projekten, einschließlich
Multi-OMICS-Ansätzen.
- Schulung & Wissenstransfer: Etablierung und Durchführung von Workshops und
Trainings für Forschende und Studierende in Bioinformatik und Statistik.
Sicherstellung der Durchführung von Pflichtkursen. Entwicklung und Pflege von
Dokumentationen und Richtlinien für bioinformatische und statistische Methoden.
Unterstützung bei der Erstellung von Publikationen und Anträgen.
- Vernetzung & Öffentlichkeitsarbeit: Aufbau starker Kooperationsnetzwerke
mit anderen Core Facilities, externen Partnern und anderen
Helmholtz-Einrichtungen im Bereich Datenanalyse. Präsentation der Core Facility
auf Konferenzen und Workshops.
- Technische & administrative Aufgaben: Verwaltung von Rechenressourcen,
Softwareinfrastruktur und High-Performance-Computing Clusters (HPC).
Gewährleistung von Datenschutz, FAIR-Datenprinzipien und regulatorischer
Compliance. Effiziente Budget- und Ressourcenverwaltung, Durchführung der
internen Kostenverrechnung.

Dein Profil

- Promotion in Bioinformatik, Biostatistik, Computerbiologie, Genomik oder
einem verwandten Fachgebiet (oder Masterabschluss mit 10 Jahren einschlägiger
Berufserfahrung)
- Mindestens 5 Jahre Erfahrung in der Bioinformatik und 3 Jahre
Führungserfahrung (Leitung eines Teams hochqualifizierter Fachleute)
- Fundierte, aktuelle Kenntnisse und praktische Erfahrung in der Genomik und
Metagenomik Datenanalyse.
- Praktische Erfahrung mit Bioinformatik-Tools und -Software (z. B. Scanpy,
Bioconductor, Seurat, Proteome Discoverer)
- Tiefes Verständnis statistischer und Machine Learning-Methoden für die
biologische Datenanalyse und die Multi-omics Integration
- Gute Programmierkenntnisse (Python, R) und Kenntnisse von Werkzeugen zur
Automatisierung von Arbeitsabläufen (Nextflow, Snakemake)
- Erfahrung mit statistischer Modellierung, Bayesi'scher Inferenz und
Hypothesentests
- Umfangreiche praktische Erfahrung in der Lehre: Erstellung und Präsentation
von Kursen in Biostatistik und Bioinformatik
- Fachwissen und praktische Erfahrung mit HPC-Umgebungen, Cloud Computing,
Linux/Unix und Datenbankmanagement
- Engagement für exzellenten Kundenservice und Bereitschaft zur
kontinuierlichen Weiter- und Neuentwicklung von Methoden
- Ausgezeichnete Kommunikationsfähigkeiten sowie fließende Deutsch- und
Englischkenntnisse (mündlich und schriftlich)

Wünschenswerte Qualifikationen

- Erfahrung in einer akademischen/ klinischen oder industriebasierten
Multiuser-Core Facility bevorzugt
- Führungskompetenz mit Fokus auf Teamkultur und Weiterentwicklung von
Mitarbeitenden
- Kenntnisse in weiteren Programmiersprachen

Bei Vorliegen der Voraussetzungen ist eine Eingruppierung bis E 15 möglich.
Sozialleistungen richten sich nach dem Tarifvertrag für den öffentlichen Dienst
(Bund). Die Stelle ist (zunächst) auf 2 Jahre befristet, eine unbefristete
Anstellung ist vorgesehen.

Geschäftsführer Matthias Tschöp und Mike Frieser:

„Wir glauben, dass Vielfalt der Schlüssel zu bahnbrechender Forschung und
innovativen Lösungen ist. Unsere flexiblen Arbeitszeitmodelle und die
Möglichkeit zum mobilen Arbeiten schaffen ein geeignetes Umfeld für die
Vereinbarkeit von Beruf und Privatleben. Für uns ist der Beitrag zu einer
gesünderen Gesellschaft an einem so inspirierenden Arbeitsplatz wirklich
wertvoll.“

Lerne uns kennen

Benefits

- Gesundheitsangebote
Sport, Betriebsarzt, mentale Gesundheit
- Vorsorge fürs Alter
Betriebliche Altersversorgung
- Leadership stärken
vielfältige, maßgeschneiderte Entwicklungsprogramme für Führungskräfte
- Familienfreundlich
KITA, Ferienbetreuung, Elder Care
- International Staff Service
unterstützt beim Start und Aufenthalt in Deutschland
- Work-Life-Balance
flexible Arbeitszeiten & Arbeitszeitmodelle

Interesse geweckt?

Falls noch Fragen offen sind, hilft gerne Susanne Heck, +49 89 318749004,
weiter.

Postdoc (f/m/x) in Cardiometabolic Disease Epidemiology

102689

Full time
39 hrs./week

Neuherberg near Munich

At Helmholtz Munich, we develop groundbreaking solutions for a healthier
society in a rapidly changing world. We believe that diverse perspectives drive
innovation. Through strong partnerships, we accelerate the transfer of new
ideas from the lab to real-life applications, improving lives.

The Institute of Epidemiology (EPI)is examining the protective and harmful
effects of the environment, genes and lifestyle on human health and disease
using population-based epidemiologic approaches. We are seeking aResearch
Scientist (f/m/x) in cardiometabolic disease epidemiology.

Your tasks

- Analyze data using R or SAS and contribute to the interpretation of results
- Write scientific reports and papers in the field of cardiometabolic disease
epidemiology
- Participate in the drafting of proposals for grants
- Support the design and planning of future studies
- Collaborate with team members to support ongoing research projects

Your profile

- PhD Degree in a relevant field such as Epidemiology, (Bio)Statistics or
Bioinformatics
- Strong analytical skills, including familiarity with statistical software
such as R and SAS
- Hands-on experience in analysis of large epidemiological datasets
preferably including omics data
- Understanding of biological process and metabolic physiology
- Very good command of English

Desirable qualification

- Knowledge of German will be an asset

If you fulfil all the requirements, you may be eligible for a salary grade of
up to E 13. Social benefits are based on the Collective Wage Agreement for
Public-Sector Employees (TVöD). The position has an (initial) fixed term of 2
years but may be extended under certain circumstances.

Managing Directors Matthias Tschöp and Mike Frieser:

„We believe that diversity is the key to groundbreaking research and
innovative solutions. Our flexible working models and remote options create a
supportive environment for balancing work and family life. For us, contributing
to a healthier society in such an inspiring workplace is truly meaningful.“

Get to know us

Benefits

- Career Development
Postdoc program, scientific training & career center with tailored offers
- Recreation
30 days annual leave, flexi days, plus public holidays
- International Staff Service
Support with the relocation and integration process in Germany
- Health Promotion
Sports, company doctor, mental health initiatives
- Scientific Resources
State-of-the-art infrastruture and Core Facilities
- Family Support
On-site kindergarten, holiday care, care for the elderly

Interested in applying?

If you have any questions, feel free to contact Barbara Thorand, 089
3187-4480, who will be happy to help.

Ludwig-Maximilians-Universität München is a leading research university in Europe. Since its founding in 1472 it has been committed to the highest international standards of excellence in research and teaching.

Institution Faculty of Medicine - Biomedical Center, Physiological Chemistry Department

Remuneration group TV-L

Full-time / Part-time Full-time (100%)

Start date Flexible, between July and September 2025

Application deadline 2025-04-30

About us:

The Russo lab is a new research group in the Physiological Chemistry Department and is funded, among others, by an Emmy Noether (DFG) grant. We are looking for a highly motivated Computational Postdoctoral Fellow to help establish this research group from the ground up, shaping an innovative and dynamic lab environment together.

The Russo lab investigates how nuclear acyl-CoA metabolism influences chromatin remodelling, transcriptional regulation, and cellular plasticity. Although acyl-CoA-producing enzymes have been extensively studied in the mitochondrial compartment for decades, emerging evidence suggests they are also present and functional in the nucleus, where they play a key role in gene regulation.

By employing omics-based approaches, metabolite tracing, proximity-labeling, and advanced imaging techniques,

this project offers a unique opportunity to:

- Explore how nuclear metabolic enzymes functionally regulate gene expression and chromatin modifications during cellular responses to external stimuli.
- Identify novel protein-protein interactions between these nuclear metabolic enzymes and chromatin factors.
- Study the biochemical and structural properties of these metabolic enzymes in the nuclear context.

We are looking for you:

Computational Postdoctoral positions in Gene Regulation and Chromatin Metabolism (m/f/x)

in Planegg-Martinsried

Your tasks and responsibilities:

- Lead bioinformatics research on nuclear acyl-CoA metabolism and chromatin regulation.
- Analyze functional genomics and proteomics datasets to study transcriptional regulation.
- Develop and implement computational pipelines for multi-omics data integration with support from Core Facility Bioinformatics.
- Mentor PhD students in computational techniques and contribute to collaborative projects.
- Develop independent research questions and apply for competitive fellowships.

Your qualifications:

- PhD in Bioinformatics, Computational Biology, Genomics, or a related discipline.
- Experience in the analysis of functional genomics and proteomics data.
- Familiarity with chromatin and transcriptional regulation.
- Ability to work independently and collaboratively in an interdisciplinary setting.
- Strong scientific writing and communication skills.

Benefits:

- Fully funded Postdoc position with competitive salaries according to TV-L scale.
- Access to professional development programs at LMU, including workshops, training, and career support for postdoctoral researchers.
- Access to cutting-edge core facilities in genomics, proteomics, imaging, and computational biology on-site.
- Close supervision and mentorship to support scientific and career development.
- Financial support for conference participation and workshops.
- A stimulating and interdisciplinary research environment at the BMC (https://www.med.lmu.de/bmc/en/about-us/campus-life/) , LMU Munich, part of the HighTech Campus, home to leading research institutes and fostering collaboration and access to top-tier facilities.
- Work in a highly international, collaborative, and interdisciplinary research setting.
- Many opportunities to help shape our BMC initiatives (https://www.med.lmu.de/bmc/en/about-us/our-values/)  (e.g. BMC Green Lab, Public Outreach, BMC Diversity and BMC Postdoc)
- Compatibility of family and science (e.g. parent room and kindergarten on campus, school holiday and emergency child care)
- Numerous LMU employee benefits (https://www.med.lmu.de/bmc/en/jobs-career/working-here/) , e.g. discounted fitness and cultural offers, job public transport ticket, Jobbike as well as several canteens and excellent cafés on campus
- Annual special payment, 30 days of vacation and additional pension scheme

We welcome applications from all backgrounds. The promotion of diversity is an important strategic goal at BMC. This is reflected in the BMC Code of Conduct (https://www.med.lmu.de/bmc/en/about-us/our-values/bmc-code-of-conduct/) , which actively promotes diversity and equal opportunities.

Destination Germany

Do you have questions about visa requirements or degree recognition? Are you looking for housing, childcare, or trying to decide on the best health insurance? The "Research in Bavaria (https://www.research-in-bavaria.de/moving-to-germany/) " website provides help in these practical matters.

Also possible in a part-time capacity.

People with disabilities who are equally as qualified as other applicants will receive preferential treatment.

Contact:

Application Process
Interested candidates should submit a single PDF file (max. 5 MB) containing:

- Curriculum Vitae (PDF file, max. 2 pages, written in English).
- Short description of research projects carried out during your studies (e.g., PhD thesis). Please describe the rationale and goals of the research, and highlight your contributions to the results (approx. 300 words).
- Description of your general research interests (approx. 200 words).
- What do you find interesting about our research group and topics? (approx. 200 words).
- Transcript (record of study) and degree certificate for all completed degrees. Please also include any supplementary information provided by the university, if available.
- Temporary/provisional transcripts for any ongoing degree programs.
- Contact details for at least two referees, including at least one direct supervisor who has worked with you for at least six months.

Important dates
Important dates
Application deadline: 30/04/2025
Start date: Flexible, between July and September 2025
Contact & Submission: Please send applications to [email protected] (https://mailto:[email protected])  with the subject “Application for Postdoc Position – BMC_LMU Munich”.

Further websites: Russo Lab page (https://www.med.lmu.de/bmc/en/research/research-groups/russo-lab/)

Where knowledge is everything.

LMU researchers work at the highest level on the great questions affecting people, society, culture, the environment and technology — supported by experts in administration, IT and tech. Become part of LMU Munich! (https://www.lmu.de/en/about-lmu/working-at-lmu/index.html)

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Ludwig-Maximilians-Universität München
Geschwister-Scholl-Platz 1
80539 München

“Research for a life without cancer" is our mission at the German Cancer Research Center. We investigate how cancer develops, identify cancer risk factors and look for new cancer prevention strategies. We develop new methods with which tumors can be diagnosed more precisely and cancer patients can be treated more successfully. Every contribution counts – whether in research, administration or infrastructure. This is what makes our daily work so meaningful and exciting.

The Division of Microbiome and Cancer is seeking for as soon as possible a Bioinformatician.

At the Division of Microbiome and Cancer, we use both well-established and cutting-edge wet-lab techniques, a state-of-the-art germ-free mouse facility, and novel bioinformatics tools to uncover the relationships between the mammalian host, immune system, and the microbiome. We are elucidating the roles of these factors in carcinogenesis and immunotherapy efficacy while discovering predictive biomarkers for cancers and treatment outcome.

We use a variety of well-established and novel bioinformatics tools and software to explore and integrate the wealth of nucleic acid, protein, and metabolite data generated from wet-lab experiments or clinical samples. Advanced computational strategies to integrate metagenomic, transcriptomic, and proteomic data are essential to fully understand and the complexity of host-microbiome interactions in the context of cancer.

Your Tasks

We are looking for a qualified and motivated Bioinformatician to support diverse areas of pipeline development and data analysis in the area of microbiome and cancer research. The candidate will support various clinical and laboratory-driven projects by developing customized multi-omics analysis approaches and generating quantitative insights into host-microbe interactions in cancer. The datasets include, amongst others, shotgun metagenomics sequencing, bacterial strain whole genome sequencing, host whole genome and RNA sequencing, and proteomics.

Your responsibilities will include:

- Support of multi-omics host-microbiome data analysis for diverse projects
- Data visualization and interpretation of results in an inderdisciplinary team with basic researchers and clinicians
- Customization of pipelines for cutting-edge research projects
- Administration of high performance computing cluster access for research team
- Support of experimental design and statistics for research team

Your Profile

- Postdoctoral, PhD-level or MSc level experience in bioinformatics, e.g. a PhD degree in computational biology or a similar discipline. Proven track record of contributing towards reseach publications
- Previous experience with HPC cluster work and on multi-omics bioinformatics projects, ideally including shotgun metagenomics datasets
- Experience with python and/or R would be an advantage
- Interest in cancer-microbiome relationships
- Strong organizational and time management skills
- Reliability
- Structured, independent, and careful way of working
- Excellent written and oral communication skills (English)

We Offer

- Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level
- 30 days of vacation per year
- Flexible working hours
- Remuneration according to TV-L incl. occupational pension plan and capital-forming payments
- Possibility of part-time work
- Family-friendly working environment
- Sustainable travel to work: subsidized Germany job ticket
- Unleash your full potential: targeted offers for your personal development to further develop your talents
- Our Corporate Health Management Program offers a holistic approach to your well-being

Are you interested?

Then become part of the DKFZ and join us in contributing to a life without cancer!

Contact:

Dinara Burnasheva
Phone: + 49 (0)6221/42-4944

​Duration: The position is initially limited to 2 years with the possibility of prolongation.

Application Deadline: 11.04.2025

Applications by e-mail cannot be accepted.

Please also note that we cannot return applications submitted by post.

We are convinced that an innovative research and working environment thrives on the diversity of its employees. Therefore, we welcome applications from talented people, regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical ability, religion and age. People with severe disabilities are given preference if they have the same aptitude.

Notice: We are subject to the regulations of the Infection Protection Act (IfSG). Therefore, all our employees must provide proof of immunity against measles.

Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche, where every voice matters.

The Position

Das sind wir

Die globale Einheit ITOT Pharma Penzberg stellt strategische und technische IT/OT-Kompetenz für eine nachhaltige Produktion hochwertiger Gesundheitsprodukte bereit. Mit lokalen und globalen Partnern entwickeln wir Lösungen für die API-Herstellung und unterstützen den pharmazeutischen MAR-Prozess durch moderne MES-Systeme und papierlose Werkzeuge. Unsere Abteilung ist auf Störungsbehebung und datenbezogene Analyse spezialisiert und unterstützt Kunden sowie Support-Organisationen effizient durch maßgeschneiderte Lösungen. Wir sind ein gut eingespieltes, selbstständig agierendes Team und fühlen uns in einem agilen Umfeld zu Hause. In diesem agilen Umfeld ist es für uns eine Selbstverständlichkeit alle unsere Kundinnen und Kunden im Betrieb, wie auch die Support Organisationen, gezielt und effizient durch Lösungen zu unterstützen.



Das erwartet Dich
* Technischer Support für alle SIMATIC IT MES/PIROL Systeme unter Betrachtung aller Batch und PLS Schnittstellen
* Optimierung der Support-Strategie im Hinblick auf die Bedürfnisse und Skills diverser Stakeholder
* Die gesamtheitliche Betrachtung der Automatisierungsebenen im Hinblick auf gemeldete, geplante und ungeplante Ereignisse (Störungen) der Herstellprozesse sowie Koordination der Schnittstellen zwischen ITOT, MFG, MSAT, Betriebstechnik, Softwareentwicklern und Lieferant
* Betreuung und Erstellung von GMP-Dokumenten ( Spezifikationen, SOPen, u.v.m.) und Mitarbeit bei LifeCycle Projekten im GMP und Development Umfeld
* Sie unterstützen und beraten Kollegen(innen) bei der Nutzung von IT-Applikationen und führen Schulungen durch
* Bedarfsanalyse und Spezifikation für die Etablierung von Software für die Bereiche Manufacturing, Development und Forschung



Das bringst Du mit
* Erfahrung im Support von GMP-Freigabe-Tools und idealerweise im MES-Support der Produktion
* Kenntnisse in der Erstellung von Testplänen und in GMP, GAMP sowie CSV
* Abgeschlossenes naturwissenschaftliches FH- oder Bachelor Studium (Naturwissenschaften/Biotechnologie/Bioinformatik/Informatik) oder Technikerabschluss mit Berufserfahrung
* Mind. 3 Jahr Erfahrung in der Industrie im IT- / Automatisierungs-Bereich
* Fließende mündliche und schriftliche Kommunikationsfähigkeiten in Deutsch und Englisch sowie die Fähigkeit, auf allen Ebenen zu überzeugen
* Freude an der Zusammenarbeit mit Kunden in der IT-Welt
* IT-Kenntnisse (SQL, Windows, Google Applikationen) oder Offenheit für digitale Herausforderungen und Chancen der Zukunft
* Bereitschaft zur Rufbereitschaft und die Möglichkeit, innerhalb einer Stunde vor Ort zu sein bei Störungsbehebungen

Soweit so gut? Es geht noch besser.

Wir bieten dir vielfältige Top-Benefits  an unseren Standorten. Nur mit dir zusammen können wir das Leben von Patient:innen verbessern. Du machst Roche mit Deinem Beitrag einzigartig. Deswegen bieten wir außergewöhnliche Benefits, die Dich unterstützen, Dein Leben, Deine Finanzen und Deine Gesundheit so zu gestalten, wie Du es möchtest. Finde hier mehr heraus: https://go.roche.com/Kandidaten-Benefits-DE

Dauer: Diese Stelle ist auf 3 Jahre gefristet

Deine Bewerbung

Wir bitten Dich um folgende Dokumente:
* Aktueller Lebenslauf

Weitere Dokumente werden derzeit nicht zwingend benötigt. Bitte beachte vor Absendung der Bewerbung, dass im Nachgang keine weiteren Dokumente hinzugefügt werden können.

Your contact to us! With people. For people.

Do you need further support?

Please have a look at our FAQs, you will find them via https://careers.roche.com/global/en/faq.

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Roche at Penzberg, near Munich, employs more than 7,000 people. The site is one of the largest biotechnology centers in Europe and the only Roche site with research, development and production for both Pharmaceuticals and Diagnostics under one roof. From your beginning with Roche, our motivated team will welcome and support you. Numerous opportunities for personal development, flexible work hours, attractive compensation packages and special family assistance programs are available.

Roche is an Equal Opportunity Employer.