Biologist - Immunology (m/f/d)

Die Abteilung für Experimentelle Pharmakologie am Institut für Pharmazie konzentriert sich auf die eingehende Analyse von Mausmodellen für menschliche Krankheiten, die in der älteren Bevölkerung sehr häufig vorkommen (z.B. Herzinsuffizienz, Übergewicht, Brustkrebs, Demenz). Unser Fokus liegt dabei auf diskreten K+-Kanälen sowie auf Komponenten des cGMP Signalwegs. Durch unseren hypothesengetriebenen, revers pharmakologischen Ansatz konnten wir zeigen, dass die vorbenannten Signalmoleküle und Ionenkanäle wichtige regulatorische Eigenschaften besitzen und Zellmetabolismus und -proliferation, Differenzierungsprozesse sowie das Überleben von Zellen unter Stressbedingungen positiv beeinflussen. Das erhebliche präklinisch-translationale Potenzial dieser Erkenntnisse testen wir derzeit in zahlreichen in vivo Studien. Schwerpunkt der Arbeiten ist die funktionelle Aufklärung cGMP-abhängiger Signalwege bei der Entstehung der Herzmuskelschwäche. Die Arbeiten im Rahmen des Projektes werden an innovativen Mausmodellen mit konstitutiver und konditionaler Genablation und daraus gewonnenen primären 2D und 3D Zellsystemen durchgeführt. Das breite Spektrum der dabei eingesetzten Methoden erstreckt sich von modernen zell- und molekularbiologischen und hochsensitiven proteinbiochemischen Ansätzen, über dynamische Lebendzellmikroskopie (insb. der optischen Echtzeitbestimmung von Analyten in kardialen Fibroblasten und Herzmuskelzellen) bis zu State-of-the-art Bildgebungs- und Telemetrie-Verfahren in vivo. Geeignete Kandidatinnen/-en verfügen über einen Hochschulabschluss (Master oder Äquivalent) der Biochemie, Biologie, Molekularen Medizin, Pharmazie oder eines vergleichbaren Studiums der Naturwissenschaften mit überdurchschnittlicher Gesamtnote. Ausserdem wird ein aktives Interesse an den zellbiologisch und proteinbiochemischen sowie pharmakologischen Forschungsthemen und an den bildgebenden in vitro Arbeitsmethoden vorausgesetzt. Darüber hinaus erwarten wir große Motivation für die Laborarbeit, Teamfähigkeit und ein fachlich fundiertes Verständnis für fächerübergreifende Forschungsfragen sowie Aufgeschlossenheit gegenüber neuen Herausforderungen. Sehr gute Englisch- und Deutschkenntnisse in Wort und Schrift sind Einstellungsvoraussetzung.
Ein etabliertes und sehr breites Methodenspektrum
Ein kollegiales Arbeitsumfeld
Zahlreiche wissenschaftliche Kollaborationen
Umfassende Unterstützung bei der Planung der eigenen akademischen Laufbahn


Wenn Sie Interesse an unseren hochaktuellen und präklinisch relevanten Fragestellungen haben, und in einem aufgeschlossenen und internationalen Team forschen, lehren und publizieren möchten, würden wir uns freuen, Sie bald kennen zu lernen.

Die Position ist auf drei Jahre befristet, die Möglichkeit zur Promotion besteht.

Schwerbehinderte werden bei gleicher Eignung bevorzugt eingestellt.

We are seeking an Environmental Microbiologist or Geomicrobiologist for a PhD position to study the improvement of simultaneous removal of ammonium and formation of methane by applying iron mineral nanoparticles. This project will investigate cultures of anaerobic Fe(III)-reducing ammonium-oxidizing (Feammox) and methanogenic microorganisms amended with iron mineral nanoparticles for ammonium removal, phosphorous recovery and simultaneous production of methane. We will carry out laboratory batch and bioreactor experiments with geochemical and molecular analyses (qPCR, metatranscriptomics) to follow microbial growth and activity, NH4+ removal and CH4 production efficiency. In addition, the nanoparticles will be analyzed (wet-chemistry, electron microscopy, XRD, Mössbauer spectroscopy).

The PhD student will be given opportunities to be creative and innovative, to apply state-of-the art microbiological and geochemical analyses, molecular techniques, microbial physiological studies, microscopy, and spectroscopy. Requirements:

Strong background in Environmental Microbiology, Microbial Ecology and Geochemistry.
Ability to work independently and in a team.
Excellent management and communication skills.
Highly motivated for interdisciplinary research.
Good computer and language (English) skills.
Start date for successful applicant is March 2025 (or as soon as the candidate is available). Employment (TVL E13, for 3 years; 75%) will be arranged by the University of Tübingen.

Exploring the Frontiers of Microbial Cultivation - Cultivating the Uncultivables

In natural environments, microbial communities are highly diverse and complex. Many microbes within these communities remain uncultivable as pure cultures using conventional laboratory techniques, often due to their intricate interactions and dependencies on other microbes. Unlocking the potential of these elusive organisms is crucial for advancements in ecology, biotechnology, and medicine. Our research focuses on developing innovative techniques to better understand and cultivate these ‘uncultivables,’ shedding light on their unique niches and contributions to microbial ecosystems.

We are seeking a highly motivated Postdoctoral Researcher with a strong background in microbial fermentation to join our team in the Environmental Biotechnology Group ( www.envbiotech.de ) at the University of Tübingen. This position offers an exciting opportunity to work on cutting-edge approaches in microbial cultivation and isolation, utilizing advanced fermentation systems and technologies.

Operate and Optimize Fermentation Systems: Manage pure culture fermentation systems ranging from 0.5-L to 2-L bioreactors.

Conduct Long-Term Retentostat Cultivations: Perform continuous operations lasting 1-2 months to study microbial growth dynamics.

Utilize Quantitative Cultivation Techniques:

Real-time data processing and analysis.
Online monitoring of off-gas composition, acid/base dosage, influent/effluent flows, redox potential, dissolved oxygen (DO), and more.



Develop New Cultivation Technologies: Innovate and implement new methods for microbial cultivation and enrichment.

Collaborate with Multidisciplinary Team: Work closely with other researchers in our team from various fields to advance research objectives

Ph.D. in Microbiology, Biotechnology, Biochemical Engineering, or a related field.
Demonstrated experience with pure-culture fermentations.
Affinity for hands-on work with equipment and technological development.
Strong analytical and problem-solving skills.
Mastery of the English language is mandatory.
Excellent communication and teamwork abilities.

Preferably experienced with:
Retentostat cultivation methods
Membrane technologies in bioreactor systems.
Real-time data processing and analysis.
Online monitoring equipment and software

A Humboldt Research Fellowship through the Henriette Herz scouting program
A stimulating research environment within a leading institution.
Access to state-of-the-art laboratory facilities and equipment.
Opportunities for professional development and networking.
No teaching obligations, allowing full focus on research activities

Mikrobiologe / Mikrobiologin (M/W/D)

Vollzeit - 100%

DAS UNTERNEHMEN Die Intavis Peptide Services GmbH steht an vorderster Front der Peptidsynthese und bietet maßgeschneiderte Lösungen für Forscher, die in die Signaltransduktion, Proteininteraktion, Proteomik, Immunologie, Impfstoffentwicklung, personalisierte Krebsbehandlung und Antisense-Inhibition involviert sind. Unsere Verpflichtung zu Flexibilität, Zuverlässigkeit und Agilität hat uns seit über drei Jahrzehnten vorangetrieben und zu einem vertrauenswürdigen Partner bei der Förderung wissenschaftlicher Forschung gemacht.



Sind Sie bereit, Ihre Zukunft in einem dynamischen und innovativen Umfeld zu gestalten? Suchen Sie nicht weiter! Werden Sie Teil von Intavis Peptide Services GmbH, einem führenden Dienstleister in der kundenspezifischen Peptidsynthese. Da wir eine bahnbrechende Expansion in die GMP-konforme Herstellung von Peptiden und klinischen Proben starten, suchen wir einen qualifizierten und motivierten Mikrobiologen, der ein integraler Bestandteil unseres Teams sein wird.
Verantwortung für die Einhaltung der GMP-Hygienestandards in der Produktion und den Laboren
Planung und Durchführung mikrobiologischer Untersuchungen und Hygienekontrollen sowie Auswertung und Dokumentation der Ergebnisse
Organisation der Reinigungs- und Desinfektionsmaßnahmen
Management mikrobiologischer Auftragslaboratorien
Planung und Durchführung von Schulungen zu den gültigen Hygienestandards
Erstellung und Pflege von SOPs im Bereich Hygiene
Mitarbeit bei Abweichungs- und Änderungsverfahrens

Master Studium der Mikrobiologie oder eine vergleichbare Qualifikation
Praktische Erfahrung im sterilen Arbeiten an einer Sicherheitswerkbank
Erfahrung bei der Arbeit in biologischen Laboratorien mit Sicherheitsstufe
Sie verfügen über viel Eigeninitiative und Lust, neue Strukturen aufzubauen
Sie verfügen über eine sehr präzise und eigenverantwortliche Arbeitsweise
Erste Erfahrung in einem GMP- oder Reinraumumfeld sind von Vorteil
Sehr gute Deutsch- und Englischkenntnisse in Wort und Schrift

Ein unbefristetes Arbeitsverhältnis
Eine angenehme Arbeitsatmosphäre in einem dynamischen Team
Ein anspruchsvolles Aufgabengebiet mit hoher Eigenverantwortung
Berufliche Fortbildungen
JOBRAD
Regelmäßige Firmenevents
Ein familienfreundliches und expandierendes Unternehmen

(Associate) Manager for Sample Management*

Permanent employee, Full-time · Tuebingen (Germany)

Overview

We are currently seeking a(n) (Associate) Manager for Sample Management* to support our Translational Research and Biomarkers team in the development of innovative immunotherapeutic products. You will work in Tuebingen (Germany) in an interdisciplinary environment with colleagues from research and clinical development departments. Your analytical reasoning and action-oriented style as well as your organization and communication skills will contribute to the team’s success. Your main responsibilities will include but are not limited to the following tasks:

You are responsible for clinical trial sample management in a GCP environment.
You are the main point of contact for Immatics stakeholders and logistics partners, promoting synergies and transparency.
You liaise with external partners and organize remote or on-site trainings, while ensuring contractual obligations are met.
You coordinate

Sample shipment, handling and receipt from clinical sites, working with external partners and different departments within Immatics.
PBMC sample processing with clinical sites.
Sample processing with external partners (e.g., PBMC isolation).
Distribution of material to external partners.


You are responsible for streamlining processes across all different sample types.
You manage/ own central documentation tools/ central trackers and thereby keep the overview of expected received and analyzed samples.
You review all sample-associated sections of clinical trial documents (e.g., laboratory manual, SOPs).
You hold a Master’s or Ph.D. degree in life sciences, biotechnology, medicine or a related discipline and have proven your excellence. Knowledge of immunology and/ or oncology is an advantage.

We expect a high degree of independent working, analytical reasoning and excellent communication skills in English. A very good knowledge of German (CEFR level B2) is an advantage. You have highly developed organizational and communication skills. Accurate documentation of workflows is of highest importance for you. You embrace rapidly changing requirements with an open mind and show a high degree of flexibility in an environment which is marked by a constant striving for excellence and optimization. Your motivation is driven by your passion for innovation and science. You approach tasks in a structured, reliable and foresighted manner, combined with an elevated level of individual responsibility, enthusiasm and strong social skills. We are a committed and inspired team and cherish the collegial, highly motivated and family-friendly atmosphere within Immatics. Our culture allows for a high level of originality, independent thinking and initiative. We believe in supporting our employees’ professional and social skills: We enable them to join conferences and trainings as well as to enjoy our Immatics benefits - e.g. job bike, job ticket, Health Programs, childcare benefits, relocation allowance, Company summer and winter events.

Notice


* We value diversity and inclusion. Immatics N.V. and all Immatics subsidiaries are equal opportunity employers that evaluate qualified applicants without regard to color, national origin, religion, age, marital status, disability, veteran status, romantic orientation, gender identity, or other characteristics protected by law.

The University of Tübingen is one of Germany's top universities while the Interfaculty Institute of Biochemistry (IFIB) of the university is an integrated research centre covering all dimensions of modern biochemical research from atoms via molecules and cells to organisms. Studying the contribution of cytosolic chaperones to the biogenesis of mitochondrial proteins

The project will employ a broad spectrum of genetic, biochemical, and molecular cell biology methods.

The experimental work will include research stays in other labs and international collaborations.

The PhD position is part of a Priority Program fundded by the German Research Foundation (DFG) and will include coordinated activities with other participants of this Priority Program. We are looking for highly motivated candidates holding a Master degree in biochemistry, biology, molecular medicine, cell biology, or a similar program.
Dynamic group
Structured qualification program including workshops, internships, national and international co-operations, conferences, and many more measures.
Highly interdisciplinary research
Modern facilities
Research stays in other labs in Germany and abroad
Salary according to E13 (65%) for at least three years

CeCaVa, a biopharmaceutical immuno-oncology company was founded as a spin-off of CeGaT GmbH with the mission to develop personalized neoantigen-based cancer vaccines derived from tumor-specific mutations. To strengthen the team in Tübingen (Germany) and to support the preparation of first clinical trials CeCaVa is searching for an experienced


QM Expert Supplier & Process Qualification (f/m/d)


in full time. The candidate will support the management in all quality-related aspects, including the completion and maintenance of the Quality Management System (QMS) as well as the qualification and management of Contract Manufacturing Organizations (CMO) and Contract Analytical Testing Labs. The candidate ensures that the processes for manufacturing and analytical testing of investigational medicinal products (IMPs) are qualified and conducted by contractors in accordance with GxP requirements.
Contribute to the qualification and contracting of suppliers (negotiate quality agreements)
Prepare, conduct, and document audits of contractors in accordance with relevant regulations (GMP, etc.)
Together with contractors define and establish manufacturing and control strategies for drug substances (DS) and drug products (DP) to comply with cGMP/GMP guidelines
Together with contractors define and conduct qualification studies for analytical assays to be applied in clinical trials (incl. NGS, T cell activation assays)
Establish excellent working relationships, communication and quality oversight of contractors to ensure manufacturing, control and timely supply of IMPs for clinical trials
Compile and revise SOPs to finalize and maintain the QMS of CeCaVa
Perform Product Quality Reviews and manage Deviations, Lab Investigations, OOS, CAPA and Change Control processes
Liaise with internal stakeholders and report quality related occurrences to the management (Quality Management Review)
Support discussions with regulators and IND/CTA filings (e.g. support writing and review of CMC/IMPD sections)

University degree in life sciences (e.g. Biology, Biochemistry, Chemistry, Pharmacy)
Several years of professional experience in a QM/QA function in a pharmaceutical/GMPregulated environment
Practical experience in managing and qualifying contractors, among others through virtual and onsite audits, to ensure vendor compliance oversight within a GxP discipline
Proven experience in supporting the qualification of GMP manufacturing processes and analytical methods
Preferably first experiences with the oversight of QC and release of IMPs for clinical trials
Quality mindset and good knowledge of regulations and guidelines of health authorities (FDA/EMA/ICH), including cGMP/GMP/GLP/ GCP principles and USP/EP compendia
Experience in the preparation of CMC chapters (IND/IMPD/IB) is a plus
Solid understanding of Quality Systems, including preferably the management of Deviations, Lab Investigations, OOS, CAPA and Change Control procedures
Ideally basic knowledge of molecular and cell biology methods and their qualification (i.e. NGS, ELISpot, intra-cellular cytokine staining)
Excellent organizational, interpersonal and communication skills in both German and English (oral, written) as well as good negotiation skills
Self-motivated, detail-oriented team player with critical thinking, and problem-solving skills
Willingness to travel for audits

An exciting opportunity to contribute to the development of a disruptive technology for the benefit of cancer patients
Work within a dedicated team in an entrepreneurial, innovative, and open-minded working atmosphere
Flat hierarchies and easy access to all company functions
Use your expertise to help shape the company
Free drinks and fresh fruits
Job bike and Job ticket (Deutschlandticket)

CeCaVa, a biopharmaceutical immuno-oncology company was founded as a spin-off of CeGaT GmbH with the mission to develop personalized neoantigen-based cancer vaccines derived from tumor-specific mutations. To strengthen the team in Tübingen (Germany) and to support the preparation of first clinical trials CeCaVa is searching for an experienced


QM Expert Supplier & Process Qualification (f/m/d)


in full time. The candidate will support the management in all quality-related aspects, including the completion and maintenance of the Quality Management System (QMS) as well as the qualification and management of Contract Manufacturing Organizations (CMO) and Contract Analytical Testing Labs. The candidate ensures that the processes for manufacturing and analytical testing of investigational medicinal products (IMPs) are qualified and conducted by contractors in accordance with GxP requirements.
Contribute to the qualification and contracting of suppliers (negotiate quality agreements)
Prepare, conduct, and document audits of contractors in accordance with relevant regulations (GMP, etc.)
Together with contractors define and establish manufacturing and control strategies for drug substances (DS) and drug products (DP) to comply with cGMP/GMP guidelines
Together with contractors define and conduct qualification studies for analytical assays to be applied in clinical trials (incl. NGS, T cell activation assays)
Establish excellent working relationships, communication and quality oversight of contractors to ensure manufacturing, control and timely supply of IMPs for clinical trials
Compile and revise SOPs to finalize and maintain the QMS of CeCaVa
Perform Product Quality Reviews and manage Deviations, Lab Investigations, OOS, CAPA and Change Control processes
Liaise with internal stakeholders and report quality related occurrences to the management (Quality Management Review)
Support discussions with regulators and IND/CTA filings (e.g. support writing and review of CMC/IMPD sections)

University degree in life sciences (e.g. Biology, Biochemistry, Chemistry, Pharmacy)
Several years of professional experience in a QM/QA function in a pharmaceutical/GMPregulated environment
Practical experience in managing and qualifying contractors, among others through virtual and onsite audits, to ensure vendor compliance oversight within a GxP discipline
Proven experience in supporting the qualification of GMP manufacturing processes and analytical methods
Preferably first experiences with the oversight of QC and release of IMPs for clinical trials
Quality mindset and good knowledge of regulations and guidelines of health authorities (FDA/EMA/ICH), including cGMP/GMP/GLP/ GCP principles and USP/EP compendia
Experience in the preparation of CMC chapters (IND/IMPD/IB) is a plus
Solid understanding of Quality Systems, including preferably the management of Deviations, Lab Investigations, OOS, CAPA and Change Control procedures
Ideally basic knowledge of molecular and cell biology methods and their qualification (i.e. NGS, ELISpot, intra-cellular cytokine staining)
Excellent organizational, interpersonal and communication skills in both German and English (oral, written) as well as good negotiation skills
Self-motivated, detail-oriented team player with critical thinking, and problem-solving skills
Willingness to travel for audits

An exciting opportunity to contribute to the development of a disruptive technology for the benefit of cancer patients
Work within a dedicated team in an entrepreneurial, innovative, and open-minded working atmosphere
Flat hierarchies and easy access to all company functions
Use your expertise to help shape the company
Free drinks and fresh fruits
Job bike and Job ticket (Deutschlandticket)